Water intoxication due to carbamazepine.

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Water intoxication during carbamazepine treatment.

Carbamazepine has recently been shown to have a vasopressin-like action and, like chlorpropamnide, to be effective in controlling polyuria in patients with diabetes insipidus (Hartman, 1972; Uhlich et al., 1972). In the case reported here carbamazepine, which was being given to a patient suffering from depression and psychogenic polydipsia, induced inappropriate secretion of antidiuretic hormon...

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Water intoxication in epileptic patients receiving carbamazepine.

Plasma sodium and osmolality were determined in 80 adult epileptic patients receiving chronic treatment with carbamazepine and in 50 control patients treated with other anticonvulsant drugs. Mean plasma osmolality was significantly lower in the carbamazepine-treated patients but mean plasma sodium did not differ in the two groups. Hyponatraemia was found in five of the carbamazine-treated patie...

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Carbamazepine Intoxication Unresponsive to Continuous Venovenous Hemodiafiltration

s: Carbamazepine (CBZ) intoxication can be associated with severe toxicity. Highly protein-bounded, CBZ is not removed efficiently through conventional hemodialysis. we observed that serum CBZ level was decreased minimally by albumin-enhanced CVVHDF with low dialysate flow. Therefore, albumin-enhanced CVVHDF with high dialysate flow should be considered in severe CBZ intoxication, if hemoperfus...

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Exfoliative Dermatitis Due to Carbamazepine

Sir, A 57 years, male patients, frequently treated with antipsychotics in past for manic episodes, was kept on carbamazepine maintenance therapy 600 mg per day since three months. Relatives called for emergency home visit with complaints of restlessness. Not sleeping since three days, itching all over body and breathlessness. On examination there was pilling of skin all over body, multiple brui...

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Carbamazepine intoxication in alcohol dependent epileptic patients.

Carbamazepine is frequently administrated to alcohol addict patients. The aim of this study was to evaluate the influence of alcohol addiction on carbamazepine pharmacokinetics and severity of drug intoxication. The total of 158 carbamazepine intoxicated patients participated in the study (76 non-alcohol-dependent, and 82 alcohol-dependent subjects). The results of the study indicate that the l...

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ژورنال

عنوان ژورنال: BMJ

سال: 1977

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.6063.754